The San Francisco 49ers' 2024 campaign is beginning to shake out a lot like their 2020 efforts. Both years followed a Super Bowl loss, and 2020 was a disaster on the injury front. Three weeks into 2024, it's looking as if injuries will be a primary theme for head coach Kyle Shanahan's squad, which is already without All-Pro running back Christian McCaffrey (calf, Achilles) for the foreseeable future and just lost Pro Bowl defensive tackle Javon Hargrave (triceps) for the season. Star offensive weapons, George Kittle (hamstring) and Deebo Samuel (calf), have already missed time with injuries, too.